Anti-DYRK1A Polyclonal Antibody-抗体-抗体-生物在线
北京索莱宝科技有限公司--实验室产品
Anti-DYRK1A Polyclonal Antibody

Anti-DYRK1A Polyclonal Antibody

商家询价

产品名称: Anti-DYRK1A Polyclonal Antibody

英文名称: DYRK;DYRK1;HP86;MNB;MNBH;MRD7

产品编号: K001710P

产品价格: null

产品产地: 北京

品牌商标: Solarbio

更新时间: null

使用范围: WB IHC

北京索莱宝科技有限公司--实验室产品
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This gene encodes a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. This member contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat. It catalyzes its autophosphorylation on serine/threonine and tyrosine residues. It may play a significant role in a signaling pathway regulating cell proliferation and may be involved in brain development. This gene is a homolog of Drosophila mnb (minibrain) gene and rat Dyrk gene. It is localized in the Down syndrome critical region of chromosome 21, and is considered to be a strong candidate gene for learning defects associated with Down syndrome. Alternative splicing of this gene generates several transcript variants differing from each other either in the 5' UTR or in the 3' coding region. These variants encode at least five different isoforms.