RAB27B抗体Applications
| In-house applications |
ELISA, WB, IHC Application not tested? Please see our Guarantee. |
| Published applications |
IHC, WB |
Publications |
6 citations –view here |
| Species specificity |
Human,Mouse,Rat; other species not tested. |
| Published Species |
Human, mouse |
|
Images
Prev1Next
 rat spleen tissue were subjected to SDS PAGE followed by western blot with 13412-1-AP( RAB27B Antibody) at dilution of 1:1000 Immunohistochemistry of paraffin-embedded human pancreas cancer tissue slide using 13412-1-AP( RAB27B Antibody) at dilution of 1:200 (under 10x lens). Immunohistochemistry of paraffin-embedded human pancreas cancer tissue slide using 13412-1-AP( RAB27B Antibody) at dilution of 1:200 (under 40x lens).
|
| Positive WB detected in |
Rat spleen tissue, A375 cells, DU 145 cells, MCF7 cells, PC-3 cells |
| Positive IHC detected in |
Human pancreas cancer tissue, human breast cancer tissue, human colon cancer tissue, human liver cancer tissue, human prostate cancer tissue, human testis tissue |
| Recommended dilution |
WB : 1:500-1:5000
IHC : 1:50-1:500 |
RAB27B抗体Application key: WB = Western blotting, IHC = Immunohistochemistry, IF = Immunofluorescence,
IP = Immunoprecipitation
Product Information
| Source |
Rabbit |
Purification method |
Antigen affinity purification |
| Isotype |
IgG |
Storage |
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. |
Immunogen Information RAB27B抗体
| Immunogen |
RAB27B fusion protein ag4064 |
Full name |
RAB27B, member RAS oncogene family |
Calculated molecular
weight |
218aa,25 kDa |
Observed molecular
weight |
25-30 kDa |
GenBank accession
number |
BC027474 |
Gene ID (NCBI) |
5874 |
| Gene symbol |
RAB27B |
Synonyms |
C25KG, RAB27B, Ras related protein Rab 27B |
Background
|
The Rab27 GTPase subfamily consists of two closely related homologs, Rab27a and Rab27b. Northern blot analysis revealed that Rab27b is expressed significantly only in testis, in which the predominant transcript was 1.4 kb in size. An 8-kb mRNA of unknown origin was detected in many tissues. Rab27b is associated with tubulovesicle membranes in the parietal cell and Rab27b may play a role in stimulation-associated membrane recruitment and gastric acid secretion. Rab27b is recently reported as a marker for breast cancer progression. It regulates invasive growth and metastasis in ER-positive breast cancer cell lines, and increased expression is associated with poor prognosis in humans. RAB27B抗体
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