Iterative Crystallography Service：Pyrroline-5-carboxylate Reductase 1
产品名称： Iterative Crystallography Service：Pyrroline-5-carboxylate Reductase 1
英文名称： Iterative Crystallography Service：Pyrroline-5-carboxylate Reductase 1
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http://www.creative-biostructure.com/Iterative-crystallography/Iterative-crystallography-CBCRY27.htm
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Cat. No. |
CBCRY27 |
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Background |
Pyrroline-5-carboxylate reductase (P5CR) is a universal housekeeping enzyme that catalyzes the reduction of Delta(1)-pyrroline-5-carboxylate (P5C) to proline using NAD(P)H as the cofactor. The enzymatic cycle between P5C and proline is very important for the regulation of amino acid metabolism, intracellular redox potential, and apoptosis. |
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Molecular description |
Protein Classification |
Oxidoreductase |
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Structure Weight |
168155.50 Da |
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Polymer |
1 |
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Molecule |
Pyrroline-5-carboxylate reductase 1 |
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Chain Length |
321 amino acids |
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Crystal Description |
PDB ID |
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MMDB ID |
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Source |
E.coli |
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Method |
X-Ray Diffraction |
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Resolution |
3.1Å |
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Gene information |
Gene Name |
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Synonyms |
P5C; P5CR; PIG45; PP222; PYCR; P5C reductase; proliferation-inducing protein 45; pyrroline-5-carboxylate reductase 1; EC 1.5.1.2; P5C reductase 1; P5CR1 |
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UniProt ID |
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GeneID |
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Chromosome Location |
17q25.3 |
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Function |
binding; oxidoreductase activity; pyrroline-5-carboxylate resuctase activity |
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Reference |
Meng, Z., Lou, Z., Liu, Z., Li, M., Zhao, X., Bartlam, M., Rao, Z. (2006) Crystal structure of human pyrroline-5-carboxylate reductase J.Mol.Biol. 359: 1364-1377 |
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