重组人FGL1蛋白（Recombinant Human FGL1 Protein），GMP级

产品货号：GMP-TL742

产品描述（Description）

Fibrinogen-like protein 1(FGL1) is also known as HP-041, Hepassocin, HFREP-1, LFIRE-1. The protective effect of fibrinogen-like protein 1 (FGL1) in liver injury has previously been reported. However, studies have shown that FGL1 may be a predictor of GC patients and atarget for GC therapy. Immunocytochemical studies revealed that fgl1 selectively binds to defective spermatozoa in the cauda epididymidis. Northern blot analysis and in situhybridization demonstrated the high expression of fgl1 in the principal cells of the proximal cauda epididymidis. Immunofluorescence analysis using mouse fibrotic lung tissues suggested that fibrotic regions showed increased expressions of Gtse1 and Fgl1, Gtse1 and Fgl1 are suggested to be novel targets for radiation-induced lung fibrosis.

分子别名（Synonym）

FGL1、Hepassocin、HP-041、HFREP-1、LFIRE-1、HFREP1

表达宿主（Expression host）

HEK293 细胞

来源（Source）

Human

蛋白序列（Protein Sequence）

DNA 序列编码人 FGL1（Q08830-1）表达带有 His 标签在 C 末端

分子量（Molecular Weight）

重组人 FGL1 蛋白包含 295 个氨基酸，预测的理论分子量为 34kD

纯度（Purity）

≥95%采用 SDS-PAGE 凝胶和高效液相色谱分析

内毒素（Endotoxin）

＜0.1EU/ug

生物活性（Biological Activity）

固定人 LAG-3（ Fc 标签）的浓度是 20 μg/mL (100 μL/孔)能够结合人 FGL1 (His 标签)的线性范围是 0-10ug/mL

稳定性（Stability）

冻干制剂可在4℃保存24个月，溶解后的液体可置于-20℃保存6-12个月，避免反复冻融

参考文献

1、Fibrinogen-like Protein 1 Is a Major Immune Inhibitory Ligand of LAG-3. Wang Jun J, Sanmamed Miguel F MF, Datar Ila I, Su Tina Tianjiao TT, Ji Lan L, Sun Jingwei J, Chen Ling L, Chen Yusheng Y, Zhu Gefeng G .Cell 2019-01- 10 334-347.e12 1-2 176 DOI : 10.1002/smll.201802403 

2、Identification of molecular signatures involved in radiation-induced lung fibrosis.Jin Hee H, Kang Ga-Young GY, Jeon Seulgi S, Kim Jin-Mo JM, Park You Na YN, Cho Jaeho J. J. Mol. Med. 2019-01-01 37-47 197 

3、Fibrinogen‑ like‑ protein 1 promotes the invasion and metastasis of gastric cancer and is associated with poor prognosis.Zhang Yang Y, Qiao Hui-Xia HX, Zhou Yong-Tao YT, Hong Liang L.Mol Med Rep 2018-08-01 1465-1472 2 18

  注意：For research and manufacturing use.