PTPRC polyclonal antibody
产品名称： PTPRC polyclonal antibody
英文名称： PTPRC polyclonal antibody
产品编号： PAB3629
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of PTPRC.
- Immunogen:
- A synthetic peptide (conjugated with KLH) corresponding to C-terminus of human PTPRC.
- Host:
- Rabbit
- Reactivity:
- Human
- Form:
- Liquid
- Purification:
- Protein G purification
- Storage Buffer:
- In PBS (0.09% sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- ELISA (1:1000)
Western Blot (1:100-500)
Flow cytometry (1:10-50)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- A high-frequency polymorphism in exon 6 of the CD45 tyrosine phosphatase gene (PTPRC) resulting in altered isoform expression.
Stanton T, Boxall S, Hirai K, Dawes R, Tonks S, Yasui T, Kanaoka Y, Yuldasheva N, Ishiko O, Bodmer W, Beverley PC, Tchilian EZ.Proc Natl Acad Sci U S A. 2003 May 13;100(10):5997-6002. Epub 2003 Apr 25.
- 2.
- Negative regulation of T cell activation by placental protein 14 is mediated by the tyrosine phosphatase receptor CD45.
Rachmilewitz J, Borovsky Z, Riely GJ, Miller R, Tykocinski ML.J Biol Chem. 2003 Apr 18;278(16):14059-65. Epub 2003 Jan 29.
- 3.
- 77 C/G mutation in the tyrosine phosphatase CD45 gene and autoimmune hepatitis: evidence for a genetic link.
Vogel A, Strassburg CP, Manns MP.Genes Immun. 2003 Jan;4(1):79-81.
- Applications
- Western Blot (Cell lysate)
- The PTPRC polyclonal antibody (Cat # PAB3629) is used in Western blot to detect PTPRC in Jurkat cell lysate.
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
- Formalin-fixed and paraffin-embedded human tonsil reacted with PTPRC polyclonal antibody (Cat # PAB3629), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
- Entrez GeneID:
- 5788
- Protein Accession#:
- P08575
- Gene Name:
- PTPRC
- Gene Alias:
- B220,CD45,CD45R,GP180,LCA,LY5,T200
- Gene Description:
- protein tyrosine phosphatase, receptor type, C
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus belongs to receptor type PTP. This gene is specifically expressed in hematopoietic cells. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Four alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq
- Other Designations:
- CD45 antigen,T200 glycoprotein,T200 leukocyte common antigen,glycoprotein,leukocyte-common antigen,protein tyrosine phosphatase, receptor type, c polypeptide
- Related Disease
- Arthritis, Juvenile Rheumatoid
- Arthritis, Rheumatoid
- Ascariasis
- Autoimmune Diseases
- Cardiomyopathy, Dilated
- Diabetes Mellitus, Type 1
- Genetic Predisposition to Disease
- Graves Disease
- Hashimoto Disease
- Hepatitis B
- Hepatitis C
- Hepatitis, Autoimmune
- HIV Infections
- Inflammatory Bowel Diseases
- Lupus Erythematosus, Systemic
- Lymphopenia
- Multiple Sclerosis
- Paraparesis, Tropical Spastic
- Scleroderma, Systemic