Uniprot ID:O00257
Species Reactivity:Human
Antibody type:Polyclonal Antibody
Aliases:Chromobox protein homolog 4,Polycomb 2 homolog,Pc2,hPc2Raised in:Rabbit
Background\Function :E3 SUMO-protein ligase which facilitates SUMO1 conjugation by UBE2I. Involved in the sumoylation of HNRNPK, a p53/TP53 transcriptional coactivator, hence indirectly regulates p53/TP53 transcriptional activation resulting in p21/CDKN1A expression. Monosumoylates ZNF131. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.
Stroage Buffer:PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Purity:Antigen Affinity purified
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