Tyrphostin AG 1478
产品名称： Tyrphostin AG 1478
英文名称： Tyrphostin AG 1478
产品编号： T4182
产品价格： 0
产品产地： sigma
品牌商标： sigma
更新时间： null
使用范围： null
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产品名称
Biochem/physiol Actions
Selective inhibitor of epidermal growth factor receptor protein
Studies in human glioma cell lines (U87MG) have shown that tyrphostin AG 1478 preferentially blocks truncated as opposed to the wild-type EGFR4.
包装
1, 5 mg in ampule
Preparation Note
Tyrphostin AG 1478 dissolves in DMSO:MeOH (1:1) at 10 mg/ml to yield a clear, colorless solution. It is also soluble in methylene chloride (10 mg/ml), ethanol (10 mg/ml) and 0.1 N HCl (less than 0.4 mg/ml). However, it is insoluble in water, 2-hydroxypropyl-β-cyclode
Application
Tyrphostin AG 1478 has been used as an EGF receptor (EGFR) inhibitor in SW1353 cultures2. AG 1478 is also known to inhibit exogenous TGFα-mediated c-Met phosphorylation in A431 cells3.
性质
| Related Categories | Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience, Enzyme Inhibitors, |
| assay | ≥98% |
| solubility | 0.1 M HCl: soluble <0.4 mg/mL |
| DMSO:methanol (1:1): soluble10 mg/mL, clear, colorless | |
| ethanol: soluble10 mg/mL | |
| methylene chloride: soluble10 mg/mL | |
| 0.1 M NaOH: insoluble | |
| 2-hydroxypropyl-β-cyclode |
|
| H2O: insoluble | |
| storage temp. | 2-8°C |
| Gene Information | human ... EGFR(1956) mouse ... Egfr(13649) |