目录号 
                        
规格 
                        
价格 
                        
说明书下载 
                    
                    

                        
C586A
                        
2μg
                        
400元
                        

                    
                    

                        
C586B
                        
10μg
                        
1800元
                    
                    

                        
C586C
                        
50μg
                        
4500元
                    
                
            
            
        
        

            

            
 
            
Chitinase-3-like 2, also known as CHI3L2, chrondrocyte protein 39 and YKL-39, is a 39 kDa, secreted glycoprotein which belongs to the glycosyl hydrolase 18 family and the most closely related to human cartilage glycoprotein 39, which promotes the growth of human synovial cells as well as skin and fetal lung fibroblasts. Highest expression of CHI3L2 is in chondrocytes, followed by synoviocytes, lung and heart. It is not detected in spleen, pancreas, and liver. CHI3L2 may also be expressed in developing brain and placenta. Increased levels of CHI3L2 have been demonstrated in synovial fluids of patients with rheumatoid or osteoarthritis as well as in some other pathologies and in malignant tumors, particularly in glioblastomas. CHI3L2 may bind glycan structure with high affinity, but not heparin. It has has no chitotriosidase activity, but is likely to bind some type of glycan.
            


            ·Description

            Novoprotein Recombinant Human Chitinase 3-like 2 produced by mammalian cells expression system.Target protein is expressed with sequence (Tyr27-Leu390) of Human chitinase 3-like 2 (Uniprot #Q15782) fused with a polyhistidine tag at the C-terminus.
            


            ·Quality Control
            
Purity: Greater than 90.0% as determined by: 

            (a) Analysis by RP-HPLC. 

            (b) Analysis by reducing and non-reducing SDS-PAGE Silver Stained gel. 

             
            
Endotoxin:Less than 0.1ng/μg (1EU/μg) of Chitinase 3-like 2 (Human)
            
 
            
·Formulation

              Novoprotein Recombinant Human Chitinase-3-like 2 was lyophilized at 1mg/ml in 20mM PBS.
            
·Reconstitution

            We recommend a quick spin followed by reconstitution of Novoprotein Recombinant Human Chitinase-3-like 2 in sterile 18MΩ-cm H2O not less than 100μg/ml, which can then be further diluted to working solutions.
            
·Storage 

            Lyophilized Recombinant Human Chitinase-3-like 2 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution Recombinant Human Chitinase-3-like 2 should be stored at 4°C between 2-7 days and aliquots of reconstituted samples are stable up to 3 months below -18°C for future use.
            
 
            
Please avoid freeze-thaw cycles.