TGFβ/ BMP信号通路ChIP qPCR芯片(TGFβ/ BMP Signaling Pathway EpiTect CHIP qPCR Array)
产品名称： TGFβ/ BMP信号通路ChIP qPCR芯片(TGFβ/ BMP Signaling Pathway EpiTect CHIP qPCR Array)
英文名称： TGFβ/ BMP Signaling Pathway EpiTect CHIP qPCR Array
产品编号： yb245
产品价格： 4800
产品产地： null
品牌商标： null
更新时间： null
使用范围： null
- 联系人 : 谷小姐
- 地址 : 上海市闵行区浦江镇联航路1239弄8B号3楼
- 邮编 : 201112
- 所在区域 : 上海
- 电话 : 181****9791 点击查看
- 传真 : 点击查看
- 邮箱 : gulingzhi@yingbio.com
|
EpiTect ChIP qPCR Array |
|
Product |
Species |
Technology |
Cat. No. |
|
Human |
|||
|
Mouse |
TGFβ/ BMP信号通路ChIP qPCR芯片分析TGFß和BMP-mediated信号在致癌作用上的84个关键基因的组蛋白修饰状态或组蛋白密码。组蛋白修饰调节染色质结构和与相关基因的转录活性。TGFß信号分子家庭包括4个主要信号通路:TGFß、骨形态发生蛋白(BMP)、节点、苯丙酸诺龙。TGFβ/ BMP信号通路在肿瘤形成的早期抑制肿瘤生长,但随后刺激转移在以后的阶段。这些信号通路在癌症中失调引起表观遗传变化,包括染色质结构的改变,如组蛋白脱乙酰作用。这个芯片包含TGFß超级家族的成员及其细胞因子和受体,以及下游信号分子和靶基因。这个芯片的结果助于进一步了解TGFß信号通路的组蛋白修饰状态,这可能阐述疾病恶化的潜在机制。通过染色质免疫沉淀和EpiTect ChIP qPCR芯片，可以很简易、可靠地分析组蛋白的化学修饰模式与TGFß和BMP介导信号通路重要基因的关联。
EpiTect ChIP qPCR仅用于分子生物学应用。本产品不用于疾病的诊断、预防和治疗
TGF-b Superfamily Ligands and Cofactors:
TGFβ:DCN, TGFB1, TGFB2, TGFB3, THBS1.
BMP:BMP1, BMP2, BMP3, BMP4, BMP5, BMP6, BMP7.
GDF: AMH, GDF2 (BMP9), GDF3 (Vgr-2), GDF5 (CDMP-1), GDF6, IGF1, IGFBP3, IL6, INHA, INHBA, LEFTY1, LTBP1, LTBP2, LTBP4, NODAL, PDGFB.
Activin:INHA, INHBA, INHBB, LEFTY1, NODAL.
Receptors:ACVR1 (ALK2), ACVR2A, ACVRL1 (ALK1), AMHR2, BMPR1A (ALK3), BMPR1B (ALK6), BMPR2, LTBP1, STAT1, TGFB1I1, TGFBR1 (ALK5), TGFBR2, TGFBR3, TGFBRAP1.
SMADs and Cofactors:SMAD1 (MADH1), SMAD3 (MADH3), SMAD4 (MADH4), SMAD5 (MADH5), SMAD7, Zfyve9.
SMAD Target Genes:
TGF-bβ/ Activin-Responsive:ATF4, CDKN1A (p21WAF1/p21CIP1), CDKN1B (p27KIP1), CDKN2B (p15INK4B), COL1A1, COL1A2, COL3A1, EMP1, FOS, GADD45B, GSC, HERPUD1, IFRD1, IGF1, IGFBP3, IL6, JUN, JUNB, MYC, PDGFB, SERPINE1 (PAI-1), TGFB1I1, TSC22D1 (TGFB1I4), TGFBI, TGIF1, TNFSF10.
BMP-Responsive: BGLAP, DLX2, ID1, ID2, JUNB, SOX4, STAT1.
Molecules Regulating Signaling of the TGF-bSuperfamily: BAMBI, BMPER, CDKN2B (p15LNK2B), CHRD, ENG (Evi-1), EVI1, FST, HIPK2, NOG, PLAU (uPA), RUNX1 (AML1).
Adhesion and Extracellular Molecules:
Adhesion Molecules: BGLAP, ENG (Evi-1), TGFB1I1, TGFBI.
Extracellular Matrix Structural Constituents: BGLAP, COL1A1, COL1A2, COL3A1, LTBP1, LTBP2, LTBP4, TGFBI.
Other Extracellular Molecules: AMH, BMP1, BMP2, FST, GDF2 (BMP9), GDF3 (Vgr-2), IGF1, IGFBP3, IL6, INHA, INHBA, INHBB, PDGFB, PLAU (uPA), SERPINE1 (PAI-1).
Transcription Factors and Regulators:DLX2, EVI1, FOS, GSC, HIPK2, ID1, JUN, JUNB, MYC, RUNX1 (AML1), SMAD1 (MADH1), SMAD3 (MADH3), SMAD4 (MADH4), SMAD5 (MADH5), SOX4, STAT1, TGFB1I1, TSC22D1 (TGFB1I4), TGIF1, ZFYVE9.
Genes Involved in Cellular and Developmental Processes:
Apoptosis:CDKN1A (p21WAF1/CIP1), HIPK2, IGFBP3, INHA, INHBA, STAT1, TGFB1.
Embryonic Development:BMP4, INHBA, SMAD3.
Muscle Development: IGF1, SMAD3.
Neurogenesis: DLX2, INHA, INHBA, NOG.
Reproduction: AMH, AMHR2, FST, INHA, INHBA, INHBB.
Skeletal Development: BGLAP, BMP1, BMP2, BMP3, BMP4, BMP5, BMP6, BMP7, BMPR2, CHRD, COL1A1, COL1A2, IGF1, INHA, INHBA, NOG.