PCR Array

DNA损伤信号通路PCR芯片可用于研究参与DNA损伤信号通路的84个基因的表达。相关的基因是那些与ATR/ATM信号网络和DNA损伤反应的可转录靶目标有关的基因。DNA损伤可以导致细胞周期阻滞，细胞凋亡，影响基因组稳定和修复。使通过实时定量PCR的方法，研究者即能够利用该芯片简单可靠地同时检测与DNA损伤信号通路相关的基因表达。
ATM/ATR Signaling: ATM, ATR, ATRIP, BARD1, BRCA1, CDC25A, CHEK1, CHEK2 (RAD53), CSNK2A2, FANCD2, H2AFX, HUS1, MDC1, PARP1 (ADPRT1), RAD1, RAD17, RAD50, RAD9A, RBBP8, RNF168, RNF8, SMC1A, TOPBP1, TP53. DNA Repair: Nucleotide Excision Repair: CDK7, DDB1, DDB2, ERCC1, ERCC2 (XPD), LIG1, NTHL1, OGG1, PCNA, PNKP, RPA1, SIRT1, TP53, XPA, XPC. Base-Excision Repair: APEX1, FEN1, LIG1, MBD4, MPG, NTHL1, OGG1, PARP1 (ADPRT1), PCNA, TP53, UNG, XRCC1. Mismatch Repair: ABL1, EXO1, MLH1, MLH3, MSH2, MSH3, PCNA, PMS1, PMS2, TP73. Double Strand Break Repair: ATM, BLM, BRCA1, CHEK1, H2AFX, HUS1, LIG1, MDC1, MLH1, MRE11A, NBN (NBS1), PRKDC, RAD50, RAD51, RPA1, TP53BP1, XRCC2, XRCC6 (G22P1). Other Genes: ATR, ATRIP, ATRX, BARD1, BRIP1, CHEK2 (RAD53), CIB1, CRY1, FANCA, FANCD2, FANCG, GADD45A, GADD45G, RAD1, RAD17, RAD18, RAD21, RAD51B, RAD9A, RBBP8, REV1, RNF168, RNF8, SMC1A, SUMO1, TOPBP1, XRCC3. Apoptosis: ABL1, ATM, BARD1, BAX, BBC3, BRCA1, CDKN1A (p21CIP1/WAF1), CHEK2 (RAD53), CIB1, CSNK2A2, PPP1R15A (GADD34), PRKDC, RAD21, RAD9A, SIRT1, TP53, TP73. Cell Cycle: ATM, ATR, ATRIP, CDC25A, CDC25C, CDK7, CDKN1A (p21CIP1/WAF1), CHEK1, CHEK2 (RAD53), DDIT3 (GADD153/CHOP), MAPK12, MCPH1, MDC1, PPM1D, PPP1R15A (GADD34), TP53, TP73