GJB2 polyclonal antibody
产品名称： GJB2 polyclonal antibody
英文名称： GJB2 polyclonal antibody
产品编号： PAB3582
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of GJB2.
- Immunogen:
- A synthetic peptide (conjugated with KLH) corresponding to C-terminus of human GJB2.
- Host:
- Rabbit
- Reactivity:
- Human, Mouse
- Form:
- Liquid
- Purification:
- Protein G purification
- Storage Buffer:
- In PBS (0.09% sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- ELISA (1:1000)
Western Blot (1:100-500)
Immunohistochemistry (1:50-100)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Inhibition of Connexin 26 by the AMP-Activated Protein Kinase.
Alesutan I, Sopjani M, Munoz C, Fraser S, Kemp BE, Foller M, Lang F.J Membr Biol. 2011 Apr;240(3):151-8. Epub 2011 Mar 12.
- 2.
- Novel mutations in GJB2 encoding connexin-26 in Japanese patients with keratitis-ichthyosis-deafness syndrome.
Yotsumoto S, Hashiguchi T, Chen X, Ohtake N, Tomitaka A, Akamatsu H, Matsunaga K, Shiraishi S, Miura H, Adachi J, Kanzaki T.Br J Dermatol. 2003 Apr;148(4):649-53.
- 3.
- GJB2 deafness gene shows a specific spectrum of mutations in Japan, including a frequent founder mutation.
Ohtsuka A, Yuge I, Kimura S, Namba A, Abe S, Van Laer L, Van Camp G, Usami S.Hum Genet. 2003 Apr;112(4):329-33. Epub 2003 Jan 31.
- 4.
- The novel R75Q mutation in the GJB2 gene causes autosomal dominant hearing loss and palmoplantar keratoderma in a Turkish family.
Uyguner O, Tukel T, Baykal C, Eris H, Emiroglu M, Hafiz G, Ghanbari A, Baserer N, Yuksel-Apak M, Wollnik B.Clin Genet. 2002 Oct;62(4):306-9.
- Applications
- Western Blot (Tissue lysate)
- The GJB2 polyclonal antibody (Cat # PAB3582) is used in Western blot to detect GJB2 in mouse brain tissue lysate.
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
- Formalin-fixed and paraffin-embedded human hepatocellular carcinoma tissue reacted with GJB2 polyclonal antibody (Cat # PAB3582) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated. HC = hepatocarcinoma.
- Entrez GeneID:
- 2706
- Protein Accession#:
- P29033
- Gene Name:
- GJB2
- Gene Alias:
- CX26,DFNA3,DFNB1,HID,KID,NSRD1,PPK
- Gene Description:
- gap junction protein, beta 2, 26kDa
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene encodes a member of the gap junction protein family. The gap junctions were first characterized by electron microscopy as regionally specialized structures on plasma membranes of contacting adherent cells. These structures were shown to consist of cell-to-cell channels that facilitate the transfer of ions and small molecules between cells. The gap junction proteins, also known as connexins, purified from fractions of enriched gap junctions from different tissues differ. According to sequence similarities at the nucleotide and amino acid levels, the gap junction proteins are divided into two categories, alpha and beta. Mutations in this gene are responsible for as much as 50% of pre-lingual, recessive deafness. [provided by RefSeq
- Other Designations:
- OTTHUMP00000018093,OTTHUMP00000018094,connexin 26,gap junction protein beta 2,gap junction protein, beta 2, 26kD (connexin 26)
- Related Disease
- Aminoglycoside-induced deafness
- Apraxias
- Attention Deficit Disorder with Hyperactivity
- Auditory Perception
- Auditory Threshold
- Cholesteatoma
- Chorioamnionitis
- Chromosome Aberrations
- Chromosome Deletion
- Chronic Disease
- Cleft Lip
- Cleft Palate
- Cognition
- Cytomegalovirus Infections
- Deafness
- Deafness
- Disease Progression
- Diseases in Twins
- Fetal Membranes, Premature Rupture