阿霉素 盐酸盐
产品名称： 阿霉素 盐酸盐
英文名称： Doxorubicin hydrochloride
产品编号： 44583
产品价格： 0
产品产地： sigma
品牌商标： sigma
更新时间： null
使用范围： null
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产品名称
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Application
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Doxorubicin is used as an antitumour antibiotic, to induce apoptosis, and to induce cardiotoxicity in SK-N-MC cells 2,3.
Used to inhibit macromolecular biosynthsis.
Biochem/physiol Actions
Antitumour antibiotic. Effect of adriamycin® on heart mitochondrial DNA;4 Properties.5,6
Inhibitor of reverse transcriptase and RNA polymerase; immunosuppressive agent; intercalates in DNA.
Doxorubicin intercalates DNA and inhibits macromolecular biosynthesis. DNA replication is haulted due to the inhibition of topoisomerase II. It is an inhibitor of reverse transcriptase and RNA polymerase and is an immunosuppressive agent 1.
包装
Bottomless glass bottle. Contents are inside inserted fused cone.
法律信息
Adriamycin 注册商标 RDF Pharmacia & Upjohn S.P.A.
Protocols & Applications
性质
| Related Categories | Antibiotics, Antibiotics A to Z, Antibiotics A-F,Antibiotics by Application, Antineoplastic and Immunosuppressive Antibiotics, |
| assay | 98.0-102.0% (HPLC) |
| mp | 216 °C (dec.)(lit.) |
| solubility | H2O: soluble50 mg/mL, clear, orange to red |
| DMSO: soluble | |
| THF: soluble | |
| ethanol: soluble | |
| methanol: soluble | |
| fluorescence | λex 470 nm; λem 585 nm in ethanol |
| suitability | suitable for fluorescence |
| storage temp. | 2-8°C |