Anti-STAT5B Polyclonal Antibody-抗体-抗体-生物在线
北京索莱宝科技有限公司--实验室产品
Anti-STAT5B Polyclonal Antibody

Anti-STAT5B Polyclonal Antibody

商家询价

产品名称: Anti-STAT5B Polyclonal Antibody

英文名称: STAT5

产品编号: K001651P

产品价格: null

产品产地: 北京

品牌商标: Solarbio

更新时间: null

使用范围: WB IHC IF

北京索莱宝科技有限公司--实验室产品
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The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL.