卷曲螺旋结构域蛋白18抗体-抗体-抗体-生物在线
北京索莱宝科技有限公司
卷曲螺旋结构域蛋白18抗体

卷曲螺旋结构域蛋白18抗体

商家询价

产品名称: 卷曲螺旋结构域蛋白18抗体

英文名称: CCDC18

产品编号: bs-8189R

产品价格: null

产品产地: 北京

品牌商标: BIOSS

更新时间: 2024-12-24T14:03:51

使用范围: ELISA=1:500-1000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,

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CCDC18, also known as NY-SAR-41 or dJ717I23.1, is a 1,454 amino acid protein expressed as two isoforms and encoded by a gene mapping to human chromosome 1. Chromosome 1 is the largest human chromosome spanning about 260 million base pairs and making up 8% of the human genome. There are about 3,000 genes on chromosome 1, and considering the great number of genes there are also a large number of diseases associated with chromosome 1. Notably, the rare aging disease Hutchinson-Gilford progeria is associated with the LMNA gene which encodes lamin A. When defective, the LMNA gene product can build up in the nucleus and cause characteristic nuclear blebs. The mechanism of rapidly enhanced aging is unclear and is a topic of continuing exploration. The MUTYH gene is located on chromosome 1 and is partially responsible for familial adenomatous polyposis. Stickler syndrome, Parkinsons, Gaucher disease and Usher syndrome are also associated with chromosome 1. A breakpoint has been identified in 1q which disrupts the DISC1 gene and is linked to schizophrenia. Aberrations in chromosome 1 are found in a variety of cancers including head and neck cancer, malignant melanoma and multiple myeloma.