Anti-FRS2 (phospho Y436)抗体-抗体-抗体-生物在线
深圳市宇德立生物科技有限公司
Anti-FRS2 (phospho Y436)抗体

Anti-FRS2 (phospho Y436)抗体

商家询价

产品名称： Anti-FRS2 (phospho Y436)抗体

英文名称： FGFR signaling adaptor SNT antibody FGFR signalling adaptor antibody FGFR substrate 2 antibody FGFR-signaling adaptor SNT antibody Fibroblast growth f

产品编号： ab193363

产品价格： null

产品产地： 英国

品牌商标： abcam

更新时间： null

使用范围：

深圳市宇德立生物科技有限公司
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进入展台

      • 描述
        兔多克隆抗体to FRS2 (phospho Y436)
      • 特异性ab193363 detects endogenous levels of FRS2 only when phosphorylated at tyrosine 436.
      • 经测试应用IHC-P, WBmore details
      • 种属反应性
        与反应: Human
        预测可用于: Mouse
      • 免疫原

        Synthetic peptide corresponding to Human FRS2 (phospho Y436) conjugated to Keyhole Limpet Haemocyanin (KLH).
        Database link: Q8WU20

      • 阳性对照
        • Human brain tissue, extracts from HuvEc cells or Jurkat cells

      性能

      • 形式Liquid
      • 存放说明Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
      • 存储溶液pH: 7.40
        Preservative: 0.02% Sodium azide
        Constituents: 49% PBS, 50% Glycerol, 0.88% Sodium chloride

        PBS is without Mg2+ and Ca2+
      •  
      • 纯度Immunogen affinity purified
      • 纯化说明ab193363 was purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
      • 克隆多克隆
      • 同种型IgG
      • 研究领域

      应用

      Our Abpromise guarantee covers the use of ab193363 in the following tested applications.

      The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

      应用 Abreviews 说明
      IHC-P   1/50 - 1/100.
      WB   1/500 - 1/1000. Predicted molecular weight: 65 kDa.

      靶标

      • 功能Adapter protein that links FGR and NGF receptors to downstream signaling pathways. Involved in the activation of MAP kinases. Modulates signaling via SHC1 by competing for a common binding site on NTRK1.
      • 组织特异性Highly expressed in heart, brain, spleen, lung, liver, skeletal muscle, kidney and testis.
      • 序列相似性Contains 1 IRS-type PTB domain.
      • 翻译后修饰Phosphorylated on tyrosine residues upon stimulation by NGF.
        Ubiquitinated when tyrosine phosphorylated and in a complex with GRB2. The unphosphorylated form is not subject to ubiquitination.
      • 细胞定位Endomembrane system. Cytoplasmic, membrane-bound.

      • Anti-FRS2 (phospho Y436) antibody 图像

        • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FRS2 antibody (ab193363)
          Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FRS2 antibody (ab193363)

          Immunohistochemical analysis of paraffin-embedded Human brain tissue labelling FRS2 with ab193363 at a 1/50 dilution. Right panel has been pre-incubated with blocking peptide.

        • Western blot - Anti-FRS2 antibody (ab193363)
          Western blot - Anti-FRS2 antibody (ab193363)
          All lanes : Anti-FRS2 (phospho Y436) antibody (ab193363) at 1/500 dilution

          Lane 1 : HuvEc extract with Antigen specific peptide
          Lane 2 : Huvec extract
          Lane 3 : Jurkat extract


          Predicted band size : 65 kDa